Research
Article [ Article in English ] |
doi: 10.46683/jmvi.2022.45 |
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Epstein-Barr virus
and JC virus Reactivation in Dermatological Patients Receiving
Immunosuppressive Therapy |
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İmmünosüpressif
Tedavi Alan Dermatolojik Hastalarda Epstein-Barr virus ve JC virus
Reaktivasyonu |
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Ayşenur
BOTSALI1 [ID], Kemal
TEKİN2 [ID], Mustafa
KOCAMAN3 [ID], Oktay SARI4
[ID], Ramazan GÜMRAL5 [ID], Ümit
SAVAŞÇI6 [ID] |
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1Department of Dermatology, Gulhane Training and Research
Hospital, University of Health Sciences, Ankara, Türkiye. 2Department of Medical Microbiology,
Gulhane Training and Research Hospital, University of Health Sciences,
Ankara, Türkiye. 3Department of Medical
Microbiology, Gulhane Institute of Health Sciences, University of Health
Sciences, Ankara, Türkiye. 4Department of Family Medicine, Gulhane Training and Research
Hospital, University of Health Sciences, Ankara, Türkiye. 5Department of Medical Microbiology,
Gulhane Medical Faculty, University of Health Sciences, Ankara, Türkiye. 6Department of Infectious Diseases and Clinical Microbiology,
Gulhane Training and Research Hospital, University of Health Sciences,
Ankara, Türkiye. |
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Article
Info: Received; 23.12.2021. Accepted; 11.02.2022. Published; 20.02.2022. Correspondence: Ramazan
Gümral; Prof., Department of Medical
Microbiology, Gulhane Medical Faculty, University of Health Sciences, Ankara,
Türkiye. E-mail: rgumral@gmail.com |
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Abstract Immunosuppressive medications are the mainstay
treatment of many severe cutaneous diseases. The objective of this study was
to investigate the reactivation of certain viral agents (Epstein-Barr virus,
human cytomegalovirus, BK virus, JC virus, B19 virus, and herpes simplex
virus) in dermatology patients who underwent immunosuppressive treatment. The
study included 57 patients and they were divided into three groups based on
the treatments; patients not receiving any immunosuppressive therapy (control
group), patients treated with phototherapy only (phototherapy group), and
patients treated with systemic immunosuppressive agents (systemic
immunosuppressive therapy group). Saliva, blood, and urine samples were
collected from all patients, and these samples were analyzed for the presence
of virus-specific DNA by TaqMan-based real-time polymerase chain reaction. In
the overall study population, the positivity rate for any viral reactivation
in at least one of the investigated specimens was 31.6% (18/57). The
frequencies of viral reactivation in the control, phototherapy, and systemic
immunosuppressive treatment groups were 9.5% (2/21), 18.8% (3/16), and 65.0%
(13/20), respectively. The viral reactivation rate in patients receiving
systemic immunosuppressive treatments was significantly higher than in the
other two groups (p=0.00022 and p=0.00544), but there was no statistically
significant difference between the phototherapy and control groups. EBV (15
patients, 26.3%) and JC virus (7 patients, 12.3%) were the most frequently
detected viruses. Viral reactivation is a potential risk for dermatology
patients receiving immunosuppressive treatments and it can be considered as a
parameter of disease control and management. Our study results also reveal
that the safety profile of phototherapy is not different from the control
group in terms of viral reactivation. |
Özet İmmünosüpressif ilaçlar, birçok ciddi
dermatolojik hastalıkta temel tedavi yaklaşımıdır. Bu çalışmanın amacı,
immünosüpressif tedavi alan dermatoloji hastalarında belirli viral etkenlerin
(Epstein-Barr virus, insan sitomegalovirus, BK virus, JC virus, B19 virus ve
herpes simpleks virus) reaktivasyonunun araştırılmasıdır. Çalışma grubu 57
hastayı içeriyordu ve hastalar uygulanan tedaviler baz alınarak üç gruba
ayrıldı; herhangi bir immünosüpressif tedavi almayan hastalar (kontrol
grubu), sadece fototerapi uygulanan hastalar (fototerapi grubu) ve sistemik
immünosüpressif ilaçlarla tedavi edilen hastalar (sistemik immünosüpressif
tedavi grubu). Tüm hastalardan tükürük, kan ve idrar örnekleri toplandı ve bu
örnekler TaqMan tabanlı gerçek zamanlı polimeraz zincir reaksiyonu ile ilgili
virüs spesifik DNA'ların varlığı yönünden incelendi. Çalışma popülasyonu
genelinde incelenen örneklerinden en az birinde herhangi bir viral
reaktivasyon için pozitiflik saptanma oranı %31.6
(18/57) idi. Kontrol, fototerapi ve sistemik immünosüpressif tedavi
gruplarında viral reaktivasyon sıklığı ise sırasıyla %9.5
(2/21), %18.8 (3/16) ve %65.0 (13/20) olarak bulundu. Sistemik
immünosüpressif tedavi alan hastalarda viral reaktivasyon oranı diğer iki
gruba göre anlamlı derecede yüksekti (p=0.00022 ve p=0.00544), ancak
fototerapi ve kontrol grupları arasında istatistiksel olarak anlamlı
farklılık yoktu. EBV (15 hasta, %26.3) ve JC virus
(7 hasta, %12.3) en sık saptanan virüslerdi. Viral reaktivasyon,
immünosüpressif tedavi alan dermatoloji hastaları için potansiyel bir risktir
ve bu nedenle hastalık kontrolü ve yönetiminin bir parametresi olarak kabul
edilebilir. Çalışma sonuçlarımız ayrıca, fototerapinin güvenlik profilinin,
viral reaktivasyon açısından, kontrol grubundan farklı olmadığını ortaya
koymaktadır. |
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Keywords: Phototherapy, Systemic immunosuppressive,
Epstein-Barr virus, Human cytomegalovirus, BK virus, JC virus, B19 virus,
Herpes simplex virus. |
Anahtar kelimeler: : Fototerapi,
Sistemik immünosüpressif, Epstein-Barr virus, İnsan sitomegalovirus, BK
virus, JC virus, B19 virus, Herpes simpleks virus. |
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Cite this
article |
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Botsalı A, Tekin K, Kocaman M, Sarı O,
Gümral R, Savaşçı Ü. Epstein-Barr virus and JC virus Reactivation in Dermatological
Patients Receiving Immunosuppressive Therapy. J Mol Virol Immunol 2022; 3(1):
20-29. doi: 10.46683/jmvi.2022.45 |
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